HIV (Human Immunodeficiency Virus) is a retrovirus that replicates in human T cells, destroying them in the process of proliferation. Soon after the Baltimore Laboratory discovered NF-kappaB, we found that the two kappaB binding sites in the HIV LTR (long terminal repeat) were central controlling elements for transcription of the HIV genome. We are currently engaged in learning more about these kappaB binding sites. We are also examining the role of RelB, a subunit of NF-kappaB, in the life cycle of HIV. In addition, we are also interested in using a lentiviral vector to deliver
siRNAs targeting HIV-1 itself or its coreceptor, CCR5, for HIV-1 gene
therapy.